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ONL Therapeutics (ONL) is a clinical-stage biopharmaceutical company committed to helping patients see the future. Our mission is to develop innovative therapeutics to protect and improve the vision of patients with a range of retinal disease and conditions.

By advancing a breakthrough technology designed to prevent the death of key retinal cells caused by the activation of the natural Fas pathway, ONL is pioneering an entirely new approach to preserve sight. It is the first and only company focused on preventing Fas-mediated death of key retinal cells, which is a root cause of vision loss, a leading cause of blindness and an unaddressed medical need.
Based on its industry-leading expertise in retinal neuroprotection, ONL is developing first-in-class treatments for serious, vision-threatening retinal diseases and conditions. The company possesses a strong and wide-ranging intellectual property portfolio around both the Fas pathway and the composition of its drug candidates, as well as experienced management and expert advisory teams with decades of experience in drug development and retinal disease.
ONL’s lead therapeutic candidate, ONL1204, is a first-in-class small peptide Fas inhibitor designed to protect retinal cells from both death and inflammatory signaling pathways. ONL1204 Ophthalmic Solution is being developed for the treatment of retinal detachment, an acute condition for which the company has been granted orphan drug designation by the FDA. In addition, the company is currently developing ONL1204 in geographic atrophy associated with age-related macular degeneration, glaucoma, and other acute and chronic indications.


To help patients see the future.


Innovation: We develop and execute on new ideas designed to create value for patients Teamwork: We work together to deliver on our objectives Science-Driven: We are guided by the weight of scientific evidence Respect: We are kind to each other and we recognize the value of each team member’s contribution to accomplish our mission Trustworthiness: We are honest and add value to deliver on our objectives


To develop first-in-class therapeutics to protect the vision of patients with retinal disease.