The following scientific papers and publications highlight the exciting research that underpins ONL’s drug development activities. The research ranges from the fundamental role that the Fas pathway plays in the health and death of key retinal cells, including photoreceptors, to specific study of Fas receptor inhibition in target retinal disease indications.
Fas-Mediated Apoptosis in Retinal Detachment:
Inhibition of retinal detachment-induced apoptosis in photoreceptors by a small peptide inhibitor of the fas receptor.
Besirli CG, Chinskey ND, Zheng QD, Zacks DN.
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2177-84. doi: 10.1167/iovs.09-4439. Epub 2009 Oct 22.
Role of the Fas-signaling pathway in photoreceptor neuroprotection.
Zacks DN, Boehlke C, Richards AL, Zheng QD.
Arch Ophthalmol. 2007 Oct;125(10):1389-95.
FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment.
Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW.
Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4563-9.
Fas-Mediated Apoptosis in Other Retinal Diseases:
The role of apoptosis in age-related macular degeneration
Dunaief JL, Dentchev T, Ying GS, Milam AH.
Arch Ophthalmol. 2002 Nov;120(11):1435-42.
Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy
Valverde AM, Miranda S, García-Ramírez M, González-Rodriguez Á, Hernández C, Simó R.
Mol Vis. 2013;19:47-53. Epub 2013 Jan 7.
Background on Patient Outcomes in Retinal Detachment:
Long-term visual acuity and the duration of macular detachment: findings from a prospective population-based study.
Mitry D, Awan MA, Borooah S, Syrogiannis A, Lim-Fat C, Campbell H, Wright AF, Fleck BW, Charteris DG, Yorston D, Singh J.
Br J Ophthalmol. 2013 Feb;97(2):149-52. doi: 10.1136/bjophthalmol-2012-302330. Epub 2012 Nov 17.