The following scientific papers and publications highlight the exciting research that underpins ONL’s drug development activities. The research ranges from the fundamental role that the Fas pathway plays in the health and death of key retinal cells to specific studies of Fas receptor inhibition in target retinal disease indications.

Fas-Mediated Apoptosis in Retinal Detachment:

Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium
Matsumoto H, Murakami Y, Kataoaka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG.
Cell Death Dis. 2015 Nov 19;6:e1986. doi: 10.1038/cddis.2015.334.

Targeting Fas in Retinal Disease
Kleinman DM, Zacks DN.
Review of Ophthalmology. 2015 Sept; 22(9): 44-51.

Inhibition of retinal detachment-induced apoptosis in photoreceptors by a small peptide inhibitor of the fas receptor.
Besirli CG, Chinskey ND, Zheng QD, Zacks DN.
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2177-84. doi: 10.1167/iovs.09-4439. Epub 2009 Oct 22.

Role of the Fas-signaling pathway in photoreceptor neuroprotection.
Zacks DN, Boehlke C, Richards AL, Zheng QD.
Arch Ophthalmol. 2007 Oct;125(10):1389-95.

FAS-mediated apoptosis and its relation to intrinsic pathway activation in an experimental model of retinal detachment.
Zacks DN, Zheng QD, Han Y, Bakhru R, Miller JW.
Invest Ophthalmol Vis Sci. 2004 Dec;45(12):4563-9.

Fas-Mediated Apoptosis in Other Retinal Diseases:

Protective Effect of Met12, a Small Peptide Inhibitor of Fas, on the Retinal Pigment Epithelium and Photoreceptor After Sodium Iodate Injury
Xiao J, Yao J, Jia L, Lin C, Zacks DN.
Invest Ophthalmol Vis Sci. 2017 Mar; 58(3): 1801–1810. doi: 10.1167/iovs.16-21392

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma
Krishnan A, Fei F, Jones A, Busto P, Marshak-Rothstein A, Ksander BR, Gregory-Ksander M.
J Immunol. 2016 Dec 15;197(12):4626-4638. Epub 2016 Nov 14.

HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent
Jiang G, Wang Y, Yun J, Hajrasouliha AR, Zhao Y, Sun D, Kaplan HJ, Shao H.
J Neuroinflammation. 2015 Sep 22;12:179. doi: 10.1186/s12974-015- 0389-2.

Targeting Fas in Retinal Disease
Kleinman DM, Zacks DN.
Review of Ophthalmology. 2015 Sept; 22(9): 44-51.

The role of apoptosis in age-related macular degeneration
Dunaief JL, Dentchev T, Ying GS, Milam AH.
Arch Ophthalmol. 2002 Nov;120(11):1435-42.

Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy
Valverde AM, Miranda S, García-Ramírez M, González-Rodriguez Á, Hernández C, Simó R.
Mol Vis. 2013;19:47-53. Epub 2013 Jan 7.

Background on Patient Outcomes in Retinal Detachment:

Long-term visual acuity and the duration of macular detachment: findings from a prospective population-based study.
Mitry D, Awan MA, Borooah S, Syrogiannis A, Lim-Fat C, Campbell H, Wright AF, Fleck BW, Charteris DG, Yorston D, Singh J.
Br J Ophthalmol. 2013 Feb;97(2):149-52. doi: 10.1136/bjophthalmol-2012-302330. Epub 2012 Nov 17.

Visual recovery after retinal detachment.
Ross WH, Stockl FA.
Curr Opin Ophthalmol. 2000 Jun;11(3):191-4.

Visual recovery in macula-off rhegmatogenous retinal detachments.
Ross WH, Kozy DW.
Ophthalmology. 1998 Nov;105(11):2149-53.

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