The ability to block the activation of the Fas pathway following the interruption of the photoreceptor/RPE interface represents the most direct and upstream approach to preventing the death of key retinal cells, including photoreceptors, and preserving patients’ vision. Attempts to deactivate the apoptosis pathway further downstream have resulted in the redirection of the signals for cell death to other pathways such as necroptosis. Blocking the Fas receptor not only prevents apoptosis, but also prevents activation of necroptosis.

ONL has successfully validated the therapeutic potential of inhibiting the Fas pathway in peer-reviewed and well-accepted models of retinal detachment and dry AMD.

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